Category
Liver.
Berberine and silymarin at standardised doses, no proprietary blends.
Liver and metabolic support centres on milk thistle (silymarin) for hepatocyte support, alongside a standardised Berberis aristata blend anchored on chromium, which contributes to normal macronutrient metabolism and the maintenance of normal blood glucose levels. EX1 ships both at considered doses, with the standardisation on the label.
Why this category matters
Silymarin is the flavonolignan complex extracted from milk thistle seeds, with documented support for hepatocyte membrane stability and antioxidant defence.
Liver and metabolic support is a category where mass-market preparations dilute the active fraction with low-cost filler ingredients. Standardised silymarin at 80 percent and a standardised Berberis aristata extract remove that dilution.
A systematic review of silymarin clinical trials reports consistent hepatoprotective and antioxidant activity at doses of 280 to 420 mg/day in adults, attributed primarily to silybin (the most active flavonolignan in the silymarin complex).
Source: Phytomedicine.
How to choose a liver supplement
Berberine should be a standardised extract, not a crude powder
A standardised Berberis aristata extract anchors to a consistent active content batch to batch, rather than a variable crude powder.
Milk thistle should declare 80 percent silymarin
Below 80 percent, the active flavonolignan content drops off and the dose response loses anchoring.
Split berberine doses across the day
Berberis aristata is traditionally taken in split doses with meals rather than as a single large dose.
Avoid stacking with grapefruit juice
Several liver-support actives are metabolised by CYP3A4, the same enzyme grapefruit juice inhibits. Keep dosing windows separate.
Standardised liver supplements from EX1
Standardised extracts at the trial doses.
Related guides
Related categories
Standardised supplements, transparent dosing.
Browse the full EX1 catalog or read about the standards every formulation has to meet.